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Improving Strategies for the Diagnosis of Cardiac Amyloidosis

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source: Expert Review of Cardiovascular Therapy

year: 2015

authors: Kourelis TV, Gertz MA

summary/abstract:

Amyloidosis refers to a group of rare but potentially fatal, protein misfolding diseases. The heart is frequently involved in the most common types, that is, immunoglobulin light chain and transthyretin amyloidosis and is the single most important predictor of patient outcomes. A major limitation in improving patient outcomes, in addition to developing novel therapeutics, is the late diagnosis of the disease. Once suspected, an organ for biopsy should be targeted and the amyloid type should be identified by mass spectrometry. 

An endomyocardial biopsy should be offered if cardiac involvement is in doubt. Echocardiography, MRI and nuclear imaging can provide valuable diagnostic and prognostic information and can secure the diagnosis if amyloid has been identified in an extracardiac tissue.

organization: Mayo Clinic, USA

DOI: 10.1586/14779072.2015.1069181

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