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MAGE Genes: Prognostic Indicators in AL Amyloidosis Patients

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source: Journal of Cellular and Molecular Medicine

year: 2019

authors: Liu Y, Wen L, Ma L, Kang Y, Liu KY, Huang XJ, Ruan GR, Lu J

summary/abstract:

A high frequency of MAGE-CT (cancer testis) antigens is expressed in Multiple Myeloma (MM) patients; however, in other plasma cell dyscrasias, their potential function remains unclear. We measured the expression of MAGE-CT genes (MAGE-C1/CT7, MAGE-A3, MAGE-C2/CT10) in 105 newly diagnosed amyloid light-chain (AL) amyloidosis patients between June 2013 and January 2018 at Peking University People’s Hospital using real-time quantitative polymerase chain reaction.

 In the newly diagnosed AL patients, the positive expression rates of patients with MAGE-C1/CT7, MAGE-C2/CT10 and MAGE-A3 were 83.8% (88/105), 56.71% (38/67) and 22.0% (13/59) respectively. There was no significant correlation between organ propensity and MAGE-CT gene expression. Changes in the MAGE-C1/CT7 levels were consistent with a therapeutic effect. The expression levels of MAGE-C1/CT7, MAGE-C2/CT10 and MAGE-A3 provide potentially effective clinical indicators for auxiliary diagnoses and monitoring treatment efficacy in AL amyloidosis patients.
 
organization: Peking University Institute of Hematology, China; Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation, China; Peking University, China; Soochow University, China

DOI: 10.1111/jcmm.14475

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